Study overview
Spasticity, muscle weakness, and pain are common challenges for people living with spinal cord injury (SCI) and can affect daily activities and quality of life. This study aims to improve treatment options by examining how different forms of noninvasive spinal stimulation influence these symptoms. By identifying the most effective stimulation settings, this research may help guide future therapies that are safer and more targeted than medication-based treatments. The study uses noninvasive transcutaneous spinal stimulation (TSS) to deliver mild electrical stimulation through electrodes placed on the skin of the lower back and abdomen. Previous studies have shown that TSS can reduce spasticity without the side effects often associated with medications, but the most effective stimulation “dose” is not yet known. In this study, researchers will compare 3 different stimulation frequencies to better understand how they affect spasticity, muscle strength, and pain.
What participation involves
Participation requires coming to Shepherd Center four consecutive days per week for 2–3 hours per day over a period of 2–3 weeks. Participants will complete assessments of spasticity, muscle strength, and pain before, during, and after stimulation sessions. Each session includes 30 minutes of spinal stimulation.
Is this study right for you?
To take part in this study participants must be:
- At least 16 years of age
- Have experienced a spinal cord injury of any severity at least three months ago
- Have measurable spasticity in one or both of their legs
- Able and willing to consent to the study, authorize the use of personal health information, follow instructions, and communicate any pain or discomfort
This study is not suitable for people who:
- Have spinal conditions that are progressive or degenerative
- Have a spinal cord injury below the T12 spinal level
- Are pregnant or may become pregnant during the study
- Have untreated heart or cardiovascular problems
- Have implanted stimulators such as baclofen pumps, spinal cord stimulators, defibrillators, or diaphragmatic pacemakers
- Have active cancer or a history of cancer
- Received injections in the leg or spine within the past 6 months to manage their spasticity
- Have undergone permanent treatments for spasticity in the test leg or spine (such as certain surgeries)
The study principal investigator may determine that other health conditions could make participation unsafe.
Who to contact for more information
Jaclyn Miller, PT, DPT
Phone: 404-350-7638
Email: jaclyn.miller@shepherd.org
Jennifer Iddings, Ph.D.
Phone: 404-367-1239
Email: jennifer.iddings@shepherd.org
